Top 20 Illinois hospitals by net patient revenue

Which Illinois hospitals have the highest net patient revenue?

The list above shows a strong concentration of hospital net patient revenue among large, academic, and system-affiliated hospitals in Illinois, particularly in the Chicago metropolitan area.

The top three facilities, Northwestern Memorial Hospital, UChicago Medicine Mitchell Hospital - Hyde Park, and Rush University Medical Center, each generate roughly $2.4–$2.6 billion in net patient revenue, underscoring the outsized financial scale of major academic medical centers.

These hospitals benefit from high patient volumes, complex case mixes, specialized service lines, and strong commercial payor representation, all of which drive higher revenue per encounter.

What revenue scale reveals about hospital market influence

Hospital revenue is more than just a valuable financial metric; it’s also a useful tool for illustrating a hospital’s role in care delivery, referral networks, and competitive dynamics within local and regional healthcare ecosystems.

Revenue scale can also reflect a facility’s negotiating power with payors and vendors. High-revenue hospitals usually command stronger leverage in commercial payor contracting due to their must-have status in insurance networks.

How commercial teams can use this data

Commercial teams across the healthcare industry, including sales, marketing, strategy, and more, can use hospital revenue data in several high-impact ways to prioritize accounts, tailor messaging, and allocate resources more effectively.

First, the data is highly actionable for account prioritization and segmentation. Hospitals with the highest net patient revenue—especially large, urban, academic, and system-affiliated facilities—represent organizations with greater purchasing power, more complex operational needs, and longer sales cycles. Commercial teams can tier these hospitals as strategic or enterprise accounts, while mid- and lower-revenue hospitals may be better suited for scaled, inside-sales, or product-led motions.

Second, revenue concentration helps teams align solutions to hospital maturity and complexity. High-revenue hospitals often manage large patient volumes, complex service lines, and competitive markets, making them strong candidates for advanced analytics, market intelligence, population health tools, and enterprise data solutions.

Third, geographic clustering, particularly around major metro areas like Chicago, enables territory planning and regional strategy. Sales leaders can focus on field coverage where financial opportunity is densest, while marketing teams can design regional campaigns tailored to competitive urban markets versus suburban or downstate regions.

Where are the largest hospitals by net patient revenue located?

With more than 9 million residents, the Chicago metro area is by far the most populated area in the state. More than half of the state’s entire population lives in and around Chicago. Because of this, the majority of the largest hospitals by net patient revenue are also located in the city.

While there are some large hospitals in cities like Springfield and Evanston, seven of the top 20 hospitals on this list are located in Chicago. The highest-ranking facility outside this metro area is Evanston Hospital, which ranks at number four.

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