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Healthcare Insights

Top 50 hospitals in the U.S. by net patient revenue

Operating a hospital is expensive. From employee salaries to facility renovation, there are a number of factors that drive high operating expenses. To remain financially stable, hospitals often rely on patient revenue to keep up with such high expenses. Net patient revenue (NPR) is a key financial metric that can be used to grade hospitals’ relative financial strength.

What is net patient revenue for hospitals?

A hospital’s net patient revenue is its aggregate money generated from patient services collected from payors. It is calculated by subtracting patient discounts from total patient revenues.

Using the Definitive Healthcare HospitalView product, we have listed the top 50 hospitals in the U.S. by net patient revenue. The data comes from the Medicare Cost Report and is listed according to the most recent 12-month interval tracked in our product. Our list only considers hospitals tracked in our database that reported their NPR.

Top 50 hospitals in the U.S. by net patient revenue

Rank Definitive ID Hospital name City State  Net patient revenue  Explore dataset
541974 NewYork-Presbyterian Weill Cornell Medical Center New York NY  $                 9,309,983,744  Explore
3556 St Lukes University Hospital - Bethlehem Bethlehem PA  $                 8,944,229,376  Explore
2843 Tisch Hospital New York NY  $                 7,240,730,112  Explore
3120 Cleveland Clinic Main Campus Cleveland OH  $                 6,960,527,872  Explore
588 Stanford Hospital - 300 Pasteur Dr Palo Alto CA  $                 6,761,246,208  Explore
873 AdventHealth Orlando (FKA Florida Hospital Orlando) Orlando FL  $                 6,233,499,648  Explore
560 UCSF Helen Diller Medical Center at Parnassus Heights San Francisco CA  $                 6,146,359,296  Explore
3742 Vanderbilt University Medical Center Nashville TN  $                 6,079,872,000  Explore
2096 University Hospital Ann Arbor MI  $                 5,076,696,064  Explore
10 4017 University of Texas MD Anderson Cancer Center Houston TX  $                 4,900,379,136  Explore
11 2846 Memorial Sloan Kettering Cancer Center New York NY  $                 4,885,776,896  Explore
12 430 Cedars-Sinai Medical Center West Hollywood CA  $                 4,341,989,376  Explore
13 2973 Duke University Hospital Greenville NC  $                 4,026,979,072  Explore
14 1365 IU Health Methodist Hospital Indianapolis IN  $                 3,924,982,016  Explore
15 1973 Massachusetts General Hospital Boston MA  $                 3,879,519,232  Explore
16 3003 Atrium Health Carolinas Medical Center Charlotte NC  $                 3,733,636,608  Explore
17 2818 Strong Memorial Hospital Rochester NY  $                 3,726,425,600  Explore
18 2191 Mayo Clinic Hospital - Saint Marys Campus Rochester MN  $                 3,701,160,192  Explore
19 3571 Hospital of the University of Pennsylvania Philadelphia PA  $                 3,690,950,656  Explore
20 273024 Montefiore Hospital - Moses Campus Bronx NY  $                 3,662,064,128  Explore
21 731 Yale New Haven Hospital New Haven CT  $                 3,629,483,008  Explore
22 515 University of California Davis Medical Center (AKA UC Davis Medical Center) Sacramento CA  $                 3,613,207,296  Explore
23 2837 The Mount Sinai Hospital (AKA Mount Sinai Medical Center) New York NY  $                 3,491,073,280  Explore
24 872 Orlando Health Orlando Regional Medical Center Orlando FL  $                 3,385,817,856  Explore
25 3623 Medical University of South Carolina Medical Center Charleston SC  $                 3,280,842,496  Explore
26 3015 UNC Medical Center (FKA University of North Carolina Hospitals - Memorial Hospital) Chapel Hill NC  $                 3,167,758,080  Explore
27 2828 Long Island Jewish Medical Center New Hyde Park NY  $                 3,149,711,616  Explore
28 4222 University of Utah Hospital Salt Lake City UT  $                 3,092,013,312  Explore
29 3567 Childrens Hospital of Philadelphia (AKA CHOP) Philadelphia PA  $                 3,075,271,168  Explore
30 550 UC San Diego Medical Center San Diego CA  $                 3,061,975,808  Explore
31 4493 UW Health University Hospital Madison WI  $                 3,028,814,080  Explore
32 3525 Lehigh Valley Hospital - Cedar Crest Allentown PA  $                 3,019,742,464  Explore
33 4018 Memorial Hermann - Texas Medical Center Houston TX  $                 2,987,785,472  Explore
34 1678 Norton Hospital Louisville KY  $                 2,985,238,784  Explore
35 1969 Brigham and Womens Hospital Boston MA  $                 2,955,813,888  Explore
36 2845 Mount Sinai Beth Israel (FKA Beth Israel Medical Center) New York NY  $                 2,946,083,840  Explore
37 1631 The University of Kansas Hospital Kansas City KS  $                 2,889,708,288  Explore
38 3421 OHSU Hospital - Portland (AKA OHSU Hospital - Marquam Hill Campus) Portland OR  $                 2,870,449,152  Explore
39 395 Ronald Reagan UCLA Medical Center Los Angeles CA  $                 2,860,667,648  Explore
40 4012 Houston Methodist Hospital (FKA the Methodist Hospital) Houston TX  $                 2,848,150,016  Explore
41 6386 Texas Childrens Hospital Houston TX  $                 2,842,123,264  Explore
42 642 UCHealth University of Colorado Hospital Aurora CO  $                 2,829,595,648  Explore
43 596 Santa Clara Valley Medical Center San Jose CA  $                 2,810,125,056  Explore
44 1000 Northside Hospital Atlanta Atlanta GA  $                 2,794,552,320  Explore
45 5576 Cincinnati Childrens Burnet Campus Cincinnati OH  $                 2,765,941,248  Explore
46 2035 Corewell Health Butterworth Hospital (FKA Spectrum Health Butterworth Hospital) Grand Rapids MI  $                 2,751,030,784  Explore
47 2976 Atrium Health Wake Forest Baptist Medical Center (FKA Wake Forest Baptist Medical Center) Winston Salem NC  $                 2,718,737,920  Explore
48 851 Sylvester Comprehensive Cancer Center Miami FL  $                 2,712,977,152  Explore
49 2442 Barnes-Jewish Hospital Saint Louis MO  $                 2,701,174,528  Explore
50 3862 Methodist Hospital San Antonio TX  $                 2,665,395,712 Explore

Fig. 1 Data is from the Definitive Healthcare HospitalView product. Data is from the Medicare Cost Report and is displayed according to the most recent 12-month interval tracked in our database. Data accessed April 2025.

What hospitals have the highest net patient revenue?

The top U.S. hospital by net patient revenue is New York-Presbyterian Weill Cornell Medical Center with a total net patient revenue of $9.3 billion. Located in the largest city in the U.S., this hospital’s high patient volume is a key source of its higher net patient revenue. In fact, the short-term acute care hospital also ranks highly on our list of hospitals with the highest number of patient discharges.

In second place is St. Luke’s University Hospital – Bethlehem in Bethlehem, Pennsylvania, with an NPR of $8.9 billion. As the headquarters of the nonprofit St. Luke’s University Health Network, the University Hospital in Bethlehem is one of 15 campuses and over 300 outpatient sites in the network.

The third top hospital on our list is Tisch Hospital, also located in New York City, with $7.2 billion in net patient revenue. Like New York-Presbyterian Weill Cornell Medical Center, Tisch Hospital also sees a high volume of patients.

What types of hospitals have the highest net patient revenue?

Definitive Healthcare tracks nine different hospital types in the HospitalView product:

Of the top 50 hospitals listed above, 47 of them are short-term acute care hospitals and three are children’s hospitals. Short-term acute care hospitals are the most prevalent hospital type in the U.S., accounting for more than half of all hospitals. Children’s hospitals also tend to report higher net patient revenue than other types of hospitals due to a greater reliance on commercial insurance over Medicare.

What is the average net patient revenue of hospitals?

In the United States, the average hospital net patient revenue is about $237 million. The average NPR for the top 50 hospitals listed above is $3.9 billion.

The combined net patient revenue of the top 50 hospitals accounts for 14% of the total net patient revenue among hospitals in the U.S.

What makes a hospital profitable?

Many factors play into the profitability of a hospital or health system. Some of the richest hospitals in the U.S. likely benefit from factors such as location, health system affiliations, process improvement, and multiple revenue streams.

Hospitals in urban areas, specifically, those that are part of a large health system, are more likely to have higher profit margins and excess revenue.

Additionally, activities beyond patient care, such as investments, retail pharmacy sales, managed care premiums, and reimbursement from quality programs can potentially increase total hospital revenue.

How many of the top hospitals by NPR are part of a health system?

Of the factors that influence the profitability of a hospital, being part of a larger health system is very prevalent in this list of top 50 hospitals by NPR. Among the top hospitals listed above, 48 are part of a health system.

While many of them do not belong to the top health systems by net patient revenue, having health system affiliation alone can increase the likelihood of having more affiliated facilities, potentially driving access to more patients and higher net patient revenue.

Interestingly, Methodist Hospital in San Antonio—the 50th and final hospital on our list— belongs to HCA Healthcare, the highest-earning and largest IDN in the U.S.

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Healthcare Insights are developed with data from Definitive Healthcare’s solutions. Want even more U.S. hospital lists and healthcare insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians, and other healthcare providers.