Top 50 Hospitals in the U.S.

The following list ranks the top-performing hospitals across the U.S. by net patient revenue (NPR).  

Hospitals calculate NPR by subtracting deductions such as charitable donations, bad debt, contractual adjustments from the gross revenue received for all patient care performed.  

Top 50 hospitals by net patient revenue

Hospital Name 

City 

State 

Net Patient Revenue 

# Of Staffed Beds 

NewYork-Presbyterian/Weill Cornell Medical Center 

New York 

NY 

$5,734,047,089  

862 

Tisch Hospital 

New York 

NY 

$5,674,123,738  

725 

Cleveland Clinic Main Campus 

Cleveland 

OH 

$5,241,664,591  

1,325 

Vanderbilt University Medical Center 

Nashville 

TN 

$4,691,813,631  

626 

UCSF Helen Diller Medical Center at Parnassus Heights 

San Francisco 

CA 

$4,606,030,749  

785 

University Hospital 

Ann Arbor 

MI 

$4,028,211,053  

944 

AdventHealth Orlando (FKA Florida Hospital Orlando) 

Orlando 

FL 

$4,003,534,342  

2,247 

Stanford Hospital 

Stanford 

CA 

$3,976,584,396  

523 

University of Texas MD Anderson Cancer Center 

Houston 

TX 

$3,672,105,487  

710 

Cedars-Sinai Medical Center 

Los Angeles 

CA 

$3,550,379,003  

882 

Memorial Sloan Kettering Cancer Center 

New York 

NY 

$3,417,060,157  

514 

Emory University Hospital 

Atlanta 

GA 

$3,220,658,079  

614 

IU Health Methodist Hospital 

Indianapolis 

IN 

$3,113,206,365  

1,247 

Massachusetts General Hospital 

Boston 

MA 

$2,954,607,780  

995 

Yale New Haven Hospital 

New Haven 

CT 

$2,923,045,981  

581 

Mayo Clinic Hospital - Saint Marys Campus 

Rochester 

MN 

$2,837,714,279  

1,111 

Strong Memorial Hospital 

Rochester 

NY 

$2,702,464,192  

761 

Montefiore Hospital - Moses Campus 

Bronx 

NY 

$2,695,861,000  

1,459 

Mount Sinai Medical Center (AKA the Mount Sinai Hospital) 

New York 

NY 

$2,683,766,080  

1,087 

Duke University Hospital 

Durham 

NC 

$2,675,540,231  

960 

Orlando Health Orlando Regional Medical Center 

Orlando 

FL 

$2,561,781,315  

808 

Long Island Jewish Medical Center 

New Hyde Park 

NY 

$2,512,859,641  

524 

Atrium Health Carolinas Medical Center 

Charlotte 

NC 

$2,485,398,176  

1,119 

UC San Diego Medical Center - Hillcrest 

San Diego 

CA 

$2,476,193,001  

381 

Hospital of the University of Pennsylvania 

Philadelphia 

PA 

$2,454,906,000  

749 

CAMC General Hospital 

Charleston 

WV 

$2,439,389,928  

800 

University of California Davis Medical Center (AKA UC Davis Medical Center) 

Sacramento 

CA 

$2,412,137,971  

598 

University of Utah Hospital 

Salt Lake City 

UT 

$2,374,684,466  

472 

UNC Medical Center (FKA University of North Carolina Hospitals - Memorial Hospital) 

Chapel Hill 

NC 

$2,361,574,427  

809 

The Johns Hopkins Hospital 

Baltimore 

MD 

$2,353,829,577  

1,019 

Spectrum Health Butterworth Hospital 

Grand Rapids 

MI 

$2,329,025,938  

1,106 

University Hospital 

Madison 

WI 

$2,324,088,319  

606 

The University of Kansas Hospital 

Kansas City 

KS 

$2,296,753,778  

854 

Brigham and Womens Hospital 

Boston 

MA 

$2,282,609,958  

804 

Northside Hospital Atlanta 

Atlanta 

GA 

$2,228,962,521  

677 

Cincinnati Childrens Burnet Campus 

Cincinnati 

OH 

$2,226,690,085  

623 

UCHealth University of Colorado Hospital 

Aurora 

CO 

$2,226,475,972  

653 

Ronald Reagan UCLA Medical Center 

Los Angeles 

CA 

$2,201,926,657  

446 

Ohio State University Wexner Medical Center (AKA Ohio State University Hospital) 

Columbus 

OH 

$2,196,385,250  

1,026 

Barnes-Jewish Hospital 

Saint Louis 

MO 

$2,146,591,415  

1,274 

Froedtert Hospital 

Milwaukee 

WI 

$2,123,588,424  

676 

Houston Methodist Hospital (FKA the Methodist Hospital) 

Houston 

TX 

$2,114,391,175  

1,116 

University of Iowa Hospitals & Clinics 

Iowa City 

IA 

$2,111,110,331  

723 

OHSU Hospital - Portland (AKA OHSU Hospital - Marquam Hill Campus) 

Portland 

OR 

$2,095,415,273  

549 

Lehigh Valley Hospital - Cedar Crest 

Allentown 

PA 

$2,085,604,745  

1,061 

Childrens Hospital of Philadelphia (AKA CHOP) 

Philadelphia 

PA 

$2,059,747,363  

576 

Norton Hospital 

Louisville 

KY 

$2,046,532,968  

340 

Santa Clara Valley Medical Center 

San Jose 

CA 

$2,006,465,085  

850 

Texas Childrens Hospital 

Houston 

TX 

$1,995,259,698  

859 

Rush University Medical Center 

Chicago 

IL 

$1,992,372,740  

592 

Fig 1. Data is from Definitive Healthcare’s Hospitals & IDN database. Data is from the October 2021 Medicare Cost Report release. Data accessed February 2022.  

Which hospitals have the highest net patient revenue? 

Many hospitals on the list are bringing in billions of dollars in NPR with the top ten reporting over $3.5 billion. Combined, the top 50 hospitals earned more than $141 billion in net patient revenue. The average hospital earned roughly $2.8 billion.  

As a key indicator of a healthcare organization’s financial strength, many thought leaders believe increasing NPR to be one of the most difficult challenges hospitals face nationwide. They cite fluctuating patient volumes, decreasing reimbursement rates and constant pressure to keep up with changing regulations as the reasons why improving financial performance is such a struggle. Providers can use healthcare commercial intelligence on payor claims, patient leakage, diagnosis and procedure trends and more to optimize their revenue growth strategy.  

Where are the hospitals with the highest NPR located? 

The map of the U.S. below indicates where the 50 hospitals with the highest net patient revenues are located.  

Hospitals are economic anchors in their communities 

The majority of the top 50 hospitals are located along the east coast and the American Mid-West, and all of them serve in or near major cities. High population states like California, Texas, New York and Florida are more likely to have a hospital with high net patient revenue. 

Hospitals across the U.S. play a major role in the social and economic health of the communities they serve. According to the Bureau of Labor Statistics, hospitals employ millions of workers, with tens of thousands of new healthcare jobs being added each year. It’s predicted that the healthcare industry will grow faster and add more jobs than any other sector by 2030.  

Hospitals can support their communities in more ways than just being a major employer. With high net patient revenue, these organizations can potentially reinvest more funds into new models of care that help improve access to care in rural areas and advance cutting-edge medical research and innovation.  

Learn more

Healthcare Insights are developed with healthcare commercial intelligence from the Definitive Healthcare platform. Want even more insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians, and other healthcare providers.  

Explore our data