Healthcare Insights
Largest oncology physician group practices
Physician groups are a unique element within the healthcare market since they focus on one specialty, which eliminates competition between individual providers and encourages them to cooperate to solve common issues. Being generally smaller than hospitals also allows physician groups to easily adapt to shifting markets, helping them continually stay at the forefront of healthcare needs.
Selling your healthcare product, software, or service to physician group practices is often a lucrative decision, but it’s essential to first narrow down your list of possible outreach targets to produce more efficient sales targeting and marketing. One way in which you can narrow down your list of leads is by prioritizing specific specialty type and size. Targeting especially large oncology physician groups can often be an effective sales strategy.
How many oncology physician group practices are there in the U.S.?
According to our database, there are approximately 2,600 or more active oncology physician group practices in the U.S. However, each physician group may have several different locations to help physicians remain competitive in the market while giving them access to more patients, so this number is not indicative of the number of oncology clinics.
Why target oncology physician groups?
Physicians in oncology practices are at the forefront of treating and managing cancer. With the ever-changing oncology landscape, oncologists are reliant upon the proper equipment, technology, and trained staff to properly diagnose, treat, prevent, and manage the many different types of cancer.
The need for oncologists is continually growing, as well. Two subsets of oncology—hematology/oncology and medical oncology—are among the greatest growing primary specialties based on claims.
Therefore, targeting large oncology physician groups can offer significant sales opportunities. Physician groups typically present a stable customer base with substantial revenue potential, especially oncology, with its growing client base. Additionally, physician groups often centralize purchasing decisions, which can lead to bulk sales and long-term partnerships—the larger the network, the greater the contract.
| Rank | Definitive ID | Physician group name | State | # of physicians | Explore dataset |
|---|---|---|---|---|---|
| 1 | 1032763 | Memorial Sloan Kettering Cancer Center Physicians | NY | 1,311 | Explore |
| 2 | 553058 | Texas Oncology | TX | 878 | Explore |
| 3 | 653808 | City of Hope Physicians | CA | 841 | Explore |
| 4 | 1037404 | Dana Farber Cancer Institute Physicians | MA | 797 | Explore |
| 5 | 1056508 | Fred Hutch Cancer Center Physicians | WA | 402 | Explore |
| 6 | 641712 | Siteman Cancer Center (FKA the Memorial Cancer Center) | MO | 355 | Explore |
| 7 | 981871 | UPMC Hillman Cancer Center | PA | 310 | Explore |
| 8 | 551855 | Florida Cancer Specialists and Research Institute | FL | 304 | Explore |
| 9 | 611397 | New York Cancer and Blood Specialists (AKA North Shore Hematology Oncology Associates) | NY | 262 | Explore |
| 10 | 732076 | Fox Chase Cancer Center Physicians (FKA Fox Chase Cancer Center Medical Group Inc) | PA | 243 | Explore |
| 11 | 1101654 | St Jude Childrens Research Hospital Physicians | TN | 192 | Explore |
| 12 | 1058422 | MossRehab | PA | 187 | Explore |
| 13 | 553053 | Tennessee Oncology | TN | 183 | Explore |
| 14 | 1057242 | Miami Cancer Institute | FL | 152 | Explore |
| 15 | 602531 | Rutgers Cancer Institute of New Jersey | NJ | 117 | Explore |
Fig. 1 Analysis of data from the Definitive Healthcare PhysicianGroupView product. The number of practices represents only those listed as “active” in our database as of December 2025.
What is the largest oncology physician group in the U.S.?
The data above highlights the concentrated landscape of large physician group practices specializing in oncology and cancer care. Memorial Sloan Kettering Cancer Center Physicians, located in New York, ranks first on our list with 1,311 affiliated physicians, 400 physicians more than the next largest group.
Texas Oncology ranks second on our list with 878 affiliated physicians. Texas Oncology is one of the top physician group in Texas based on 2020 Medicare charges.
One notable insight from the data is regional distribution. New York and Pennsylvania each appear multiple times on the list, reflecting strong regional hubs for oncology care and research. States like California, Texas, Massachusetts, and Florida also appear, aligning with population density as well as the presence of major NCI-designated cancer centers.
For companies selling into oncology—whether therapeutics, diagnostics, technology, or services—these insights can help prioritize engagement with the large, multi-state networks while identifying niche but influential organizations operating in key regional markets.
Tips for targeting oncology physician groups
Once you’ve curated your target list of oncology physician groups, it’s essential to remember their key focuses and frame your offering as a solution to their needs. Consider the following to effectively engage oncologists:
Understand their needs
Data such as procedure and claims data, tech install data, and even Medicare charges can help you better understand each of your prospects and the unique challenges they face. Using these insights, you can personalize your outreach to those who can see the greatest impact of your product or service.
Highlight relevant benefits
Using your understanding of each physician group’s challenges, highlight the benefits of your product, software, or service that are relevant to their needs. Focus on how your solution can improve patient outcomes, enhance diagnostic capabilities, or optimize operations.
Showcase success stories
Provide evidence of the real-world benefits of your solution. Whether it’s clinical trial data or case studies, select success stories that are most relevant to the needs of the physician group you’re targeting.
Learn more
Healthcare Insights are developed with insights from the Definitive Healthcare platform. Want additional data points, including Medicare charges, procedure data, and claims and affiliation insights? Start a free trial now and get access to the latest insights that can help you power a more intelligent sales strategy by prioritizing the right physician groups and creating tailored messaging for their decision-makers.
