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Healthcare Insights

Most common medications for PTSD

Increased awareness of the importance of mental health is helping us take care of our minds like we take care of our bodies.

While the most common mental health conditions tend to be depression and anxiety, post-traumatic stress disorder (PTSD) also affects about 12 million U.S. adults a year.

Using data from the Definitive Healthcare ClaimsMx and ClaimsRx products, this list reviews the most common medications prescribed for PTSD between January and November 2022. The PTSD ICD-10 diagnosis codes used for analysis include:

  • F4310 post-traumatic stress disorder, unspecified
  • F4311 post-traumatic stress disorder, acute
  • F4312 post-traumatic stress disorder, chronic

Top medications prescribed for PTSD

RankDrug namePharmacy classPercent of PTSD prescriptionsExplore dataset
1PRAZOSIN HCLALPHA BLOCKERS ALONE OR COMBINATIONS16.7%Explore
2SERTRALINE HCLSSRI (SEL. SEROTONIN REUPTAKE INHIBITOR)6.7%Explore
3TRAZODONE HCLNEWER GENERATION ANTI-DEPRESSANTS5.2%Explore
4CLONAZEPAMSEIZURE DISORDERS4.7%Explore
5FLUOXETINE HCLSSRI (SEL. SEROTONIN REUPTAKE INHIBITOR)4.1%Explore
6QUETIAPINE FUMARATEANTIPSYCHOTICS, OTHERS3.9%Explore
7ESCITALOPRAM OXALATESSRI (SEL. SEROTONIN REUPTAKE INHIBITOR)3.7%Explore
8BUSPIRONE HCLANTIANXIETY, OTHERS3.7%Explore
9ALPRAZOLAMBENZODIAZEPINES3.5%Explore
10DULOXETINE HCLSNRI (SEROTONIN/NOREPI REUPTAKE INHIBIT)3.0%Explore
11HYDROXYZINE HCLANTIANXIETY, OTHERS3.0%Explore
12GABAPENTINSEIZURE DISORDERS2.8%Explore
13VENLAFAXINE HCL ERSNRI (SEROTONIN/NOREPI REUPTAKE INHIBIT)2.8%Explore
14CLONIDINE HCLCENTRALLY ACTING AGENTS, ALONE OR COMBOS2.4%Explore
15BUPROPION XLNEWER GENERATION ANTI-DEPRESSANTS2.3%Explore
16LORAZEPAMBENZODIAZEPINES2.2%Explore
17MIRTAZAPINEANTIDEPRESSANT-TRICYCLICS &TETRACYCLICS2.2%Explore
18ARIPIPRAZOLEANTIPSYCHOTICS, OTHERS2.1%Explore
19HYDROXYZINE PAMOATEANTIANXIETY, OTHERS2.1%Explore
20LAMOTRIGINESEIZURE DISORDERS2.0%Explore

Fig. 1. Data from the Definitive Healthcare ClaimsMx and Rx products. Claims data is sourced from multiple medical claims clearinghouses in the United States and updated monthly. Data accessed December 2022.

What is the most common drug prescribed for PTSD?

Prazosin is the most prescribed medication for patients with PTSD based on data in our Claims products. The drug is mostly used for high blood pressure but has also been shown to treat PTSD nightmares.

The next two medications on the list, sertraline and trazodone, are also some of the most commonly prescribed antidepressant medications. Both drugs help to increase serotonin levels in the brain.

What is PTSD?

Post-traumatic stress disorder, or PTSD, is a condition seen in people who have either experienced or witnessed an emotionally or physically harmful or life-threatening event. It has commonly been associated with combat veterans but can affect any person after they go through events such as natural disasters, serious accidents, and assaults.

Patients with PTSD can have symptoms that include flashbacks, nightmares, disturbing thoughts, and feelings of fear, anger, and sadness.

How is PTSD treated?

PTSD treatment can include talk therapy with mental health specialists, group therapy, and medications. As seen in the table above, medications typically prescribed for depression and anxiety treat many symptoms of PTSD, including:

Learn more

Healthcare Insights are developed with healthcare commercial intelligence from the Definitive Healthcare platform. Want even more insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians, and other healthcare providers.