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The following list contains the top 20 antidepressants by prescription volume for 2017, the most recent available data from the Centers for Medicare and Medicaid Services (CMS).

The drugs listed below account for nearly 39 million prescriptions, including refills. Trazadone HCL, a generic tetracyclic antidepressant used to treat anxiety and depression, ranked first with over 12 million prescriptions. With almost 9 million total prescriptions reported in 2017, Citalopram HBR was the second most highly-prescribed antidepressant in the United States.

Generically manufactured drugs were the most frequently represented, accounting for 65 percent of the top 20. Both Pfizer and Otsuka America Pharmaceutical appeared twice in the top 20.

Most Commonly Prescribed Antidepressants

Rank Product (Brand Name) Generic Drug Name Manufacturer / Packaging Company # of Prescriptions (Including Refills)
1 TRAZODONE HCL Trazodone Hcl Generic 12,027,353
2 CITALOPRAM HBR Citalopram Hydrobromide Generic 8,904,541
3 FLUOXETINE HCL Fluoxetine Hcl Edgemont Pharmaceuticals LLC 6,192,841
4 MIRTAZAPINE Mirtazapine Generic 6,060,609
5 AMITRIPTYLINE HCL Amitriptyline Hcl Generic 3,196,255
6 NORTRIPTYLINE HCL Nortriptyline Hcl Generic 1,079,849
7 TRINTELLIX Vortioxetine Hydrobromide Takeda Pharmaceuticals America Inc 273,962
8 FLUVOXAMINE MALEATE Fluvoxamine Maleate Generic 242,063
9 VIIBRYD Vilazodone Hcl Forest Laboratories Inc 198,389
10 DESVENLAFAXINE SUCCINATE ER Desvenlafaxine Succinate Pfizer Inc 192,229
11 IMIPRAMINE HCL Imipramine Hcl Generic 161,058
12 ABILIFY MAINTENA Aripiprazole Otsuka America Pharmaceutical Inc 105,862
13 CLOMIPRAMINE HCL Clomipramine Hcl Generic 91,020
14 PRISTIQ Desvenlafaxine Succinate Pfizer Inc 76,818
15 FETZIMA Levomilnacipran Hcl Allergan Inc 50,540
16 DESIPRAMINE HCL Desipramine Hcl Generic 40,354
17 PAROXETINE ER Paroxetine Hcl Generic 32,793
18 NEFAZODONE HCL Nefazodone Hcl Generic 19,360
19 ABILIFY Aripiprazole Otsuka America Pharmaceutical Inc 14,329
20 FLUVOXAMINE MALEATE ER Fluvoxamine Maleate Generic 9,346
21 PAROXETINE CR Paroxetine Hcl Generic 8,923

Fig 1. Data from Definitive Healthcare based on Drug Market Analytics from the Physicians DatabaseMedicare data is from the Centers for Medicare and Medicaid Services (CMS) Medicare Part D Prescriber Public Use File (PUF). Calendar Year data is projected to be released each fall by the CMS. The most recent available data is from calendar year 2017.