The following list contains the top 20 antidepressants by prescription volume for 2017, the most recent available data from the Centers for Medicare and Medicaid Services (CMS).

The drugs listed below account for nearly 39 million prescriptions, including refills. Trazadone HCL, a generic tetracyclic antidepressant used to treat anxiety and depression, ranked first with over 12 million prescriptions. With almost 9 million total prescriptions reported in 2017, Citalopram HBR was the second most highly-prescribed antidepressant in the United States.

Generically manufactured drugs were the most frequently represented, accounting for 65 percent of the top 20. Both Pfizer and Otsuka America Pharmaceutical appeared twice in the top 20.

Most Commonly Prescribed Antidepressants

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RankProduct (Brand Name)Generic Drug NameManufacturer / Packaging Company# of Prescriptions (Including Refills)Explore This Dataset
1TRAZODONE HCLTrazodone HclGeneric12,027,353Explore This Profile
2CITALOPRAM HBRCitalopram HydrobromideGeneric8,904,541Explore This Profile
3FLUOXETINE HCLFluoxetine HclEdgemont Pharmaceuticals LLC6,192,841Explore This Profile
4MIRTAZAPINEMirtazapineGeneric6,060,609Explore This Profile
5AMITRIPTYLINE HCLAmitriptyline HclGeneric3,196,255Explore This Profile
6NORTRIPTYLINE HCLNortriptyline HclGeneric1,079,849Explore This Profile
7TRINTELLIXVortioxetine HydrobromideTakeda Pharmaceuticals America Inc273,962Explore This Profile
8FLUVOXAMINE MALEATEFluvoxamine MaleateGeneric242,063Explore This Profile
9VIIBRYDVilazodone HclForest Laboratories Inc198,389Explore This Profile
10DESVENLAFAXINE SUCCINATE ERDesvenlafaxine SuccinatePfizer Inc192,229Explore This Profile
11IMIPRAMINE HCLImipramine HclGeneric161,058Explore This Profile
12ABILIFY MAINTENAAripiprazoleOtsuka America Pharmaceutical Inc105,862Explore This Profile
13CLOMIPRAMINE HCLClomipramine HclGeneric91,020Explore This Profile
14PRISTIQDesvenlafaxine SuccinatePfizer Inc76,818Explore This Profile
15FETZIMALevomilnacipran HclAllergan Inc50,540Explore This Profile
16DESIPRAMINE HCLDesipramine HclGeneric40,354Explore This Profile
17PAROXETINE ERParoxetine HclGeneric32,793Explore This Profile
18NEFAZODONE HCLNefazodone HclGeneric19,360Explore This Profile
19ABILIFYAripiprazoleOtsuka America Pharmaceutical Inc14,329Explore This Profile
20FLUVOXAMINE MALEATE ERFluvoxamine MaleateGeneric9,346Explore This Profile
21PAROXETINE CRParoxetine HclGeneric8,923Explore This Profile

Fig 1. Data from Definitive Healthcare based on Drug Market Analytics from the Physicians DatabaseMedicare data is from the Centers for Medicare and Medicaid Services (CMS) Medicare Part D Prescriber Public Use File (PUF). Calendar Year data is projected to be released each fall by the CMS. The most recent available data is from calendar year 2017.