The following list contains the top 20 antidepressants by prescription volume for 2017, the most recent available data from the Centers for Medicare and Medicaid Services (CMS).
The drugs listed below account for nearly 39 million prescriptions, including refills. Trazadone HCL, a generic tetracyclic antidepressant used to treat anxiety and depression, ranked first with over 12 million prescriptions. With almost 9 million total prescriptions reported in 2017, Citalopram HBR was the second most highly-prescribed antidepressant in the United States.
Generically manufactured drugs were the most frequently represented, accounting for 65 percent of the top 20. Both Pfizer and Otsuka America Pharmaceutical appeared twice in the top 20.