Healthcare Insights

Most common anti-anxiety medications

Anxiety is one of the most common mental health diagnoses in the U.S., impacting nearly 20% of the adult population.

Treatments for anxiety disorders can include therapy, medication, complementary and alternative treatment, and transcranial magnetic stimulation.

Using data from the Definitive Healthcare Atlas Prescription Claims product, we created this list of the top 20 most prescribed anti-anxiety medications dispensed to U.S. patients in 2022.

Top 20 anti-anxiety prescriptions dispensed in 2022

Rank Drug name % share of anti-anxiety drugs dispensed in U.S.Explore dataset
Gabapentin 17.6% Explore
Trazodone hydrochloride 9.5% Explore
Bupropion XL 7.7% Explore
Alprazolam 7.2% Explore
Duloxetine hydrochloride 7.1% Explore
Buspirone hydrochloride 5.6% Explore
Clonazepam 5.3% Explore
Hydroxyzine hydrochloride 4.7% Explore
Venlafaxine hydrochloride ER 4.7% Explore
10Lamotrigine 4.2% Explore
11Lorazepam 4.2% Explore
12 Topiramate 3.1% Explore
13 Levetiracetam 2.5% Explore
14 Bupropion hydrochloride SR 2.0% Explore
15 Hydroxyzine pamoate 2.0% Explore
16 Diazepam 1.9% Explore
17 Desvenlafaxine succinate ER 1.2% Explore
18Divalproex sodium 1.2% Explore
19Oxcarbazepine 1.2% Explore
20 Divalproex sodium ER  0.9% Explore

Fig. 1 Data from the Definitive Healthcare Atlas Prescription Claims product for calendar year 2022. Claims data is sourced from multiple medical claims clearinghouses in the United States and updated monthly. Accessed September 2023.

What are the most common anti-anxiety medications?

Gabapentin is the most common drug used to treat anxiety, accounting for 17.6% of prescriptions dispensed in 2022. While typically used to treat seizure disorders, the medication is also used to manage symptoms for patients with anxiety and other mental health disorders.

Trazodone hydrochloride, also a common antidepressant, is second on the list with 9.5% of anti-anxiety medication prescriptions dispensed.

The next three drugs, bupropion XL, alprazolam, and duloxetine hydrochloride, each represent 7 – 8% of anti-anxiety prescriptions dispensed in 2022. 

What are the types of drugs used to treat anxiety?

Drugs approved for treating anxiety include selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). However, medications not approved for anxiety are commonly used “off-label” in clinical practice.

The different types of drug types used to treat anxiety include:

Anxiety medication trends

Pharmaceutical and clinical research and development (R&D) for mental health condition treatments is helping more people manage their mental health. Anxiety medication R&D explores how different types of medications affect the brain. Some emerging mental health and new anxiety medications also fall into the following categories:

Learn more

Healthcare Insights are developed with healthcare commercial intelligence from the Definitive Healthcare platform. Want even more insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians, and other healthcare providers.