Healthcare Insights

Top 20 injection, infusion, and complex agent administration procedures

Medical infusion, or infusion therapy, is a medication delivery method used in the treatment of numerous diseases and conditions, including cancer, autoimmune disorders, infections, and dehydration.

By delivering medication through a needle or catheter, healthcare providers use infusion therapy to target specific body parts, avoid the diminishing impact of the digestive system on certain drugs, and dispense treatment at a controlled rate. Infusion therapies delivered intravenously are also known as IV therapies.

Under Current Procedural Terminology (CPT) standards, infusion therapy procedures are categorized under the subcategory “Medicine – injections, infusions, and complex agent administration”. Using claims data, we’ve compiled a list of these procedures ranked by their relative volume in 2021.

Top 20 infusion therapy procedures in 2021

RankHCPCS/CPT codeHCPCS/CPT description% Total proceduresAvg charge/procedureExplore dataset
196372THER/PROPH/DIAG INJ SC/IM28.50%$107 Explore
296374THER/PROPH/DIAG INJ IV PUSH14.20%$359 Explore
396375TX/PRO/DX INJ NEW DRUG ADDON12.90%$351 Explore
496365THER/PROPH/DIAG IV INF INIT8.30%$482 Explore
596361HYDRATE IV INFUSION ADD-ON8.20%$347 Explore
696413CHEMO IV INFUSION 1 HR6.40%$733 Explore
796376TX/PRO/DX INJ SAME DRUG ADON3.40%$320 Explore
896360HYDRATION IV INFUSION INIT3.20%$463 Explore
996367TX/PROPH/DG ADDL SEQ IV INF2.90%$277 Explore
1096366THER/PROPH/DIAG IV INF ADDON2.90%$377 Explore
1196415CHEMO IV INFUSION ADDL HR2.00%$366 Explore
1296417CHEMO IV INFUS EACH ADDL SEQ1.50%$436 Explore
1396401CHEMO ANTI-NEOPL SQ/IM1.40%$306 Explore
1496402CHEMO HORMON ANTINEOPL SQ/IM0.90%$243 Explore
1596368THER/DIAG CONCURRENT INF0.80%$211 Explore
1696523IRRIG DRUG DELIVERY DEVICE0.70%$183 Explore
1796411CHEMO IV PUSH ADDL DRUG0.60%$417 Explore
1896416CHEMO PROLONG INFUSE W/PUMP0.40%$842 Explore
1996409CHEMO IV PUSH SNGL DRUG0.30%$575 Explore
2096377APPLICATON ON-BODY INJECTOR0.30%$148 Explore

Fig. 1 Data is from the Definitive Healthcare ClaimsMx product for calendar year 2021. Claims data is sourced from multiple medical claims clearinghouses in the United States and is updated monthly. Data is accurate as of October 2022.

What were the most common infusion therapy procedures in 2021?

The top procedure code on our list is CPT code 96372, representing 28.5% of all procedures within this category in 2021. This code captures a broad range of therapeutic, prophylactic, and diagnostic injections and infusions (excluding chemotherapy and other highly complex drugs) injected intramuscularly or subcutaneously. The prevalence of these procedures is reflected in their cost: with an average charge per procedure of $107, they’re the least expensive on our list.

In second place is CPT code 96374, with 14.2% of total procedures in 2021. This code is the IV therapy companion to CPT code 96372, representing the intravenous delivery of therapeutic, prophylactic, and diagnostic injections and infusions (minus chemotherapy and other complex drugs).

The third-most common procedures fall under CPT code 96375, accounting for 12.9% of 2021 infusion procedures. This code refers to the administration of a new drug or other substance via IV push following the delivery of medication under CPT code 96374.

The first chemotherapy-related procedure on our list comes in at number six with 6.4% of infusion procedures in 2021: Chemotherapy IV infusion for one hour, under CPT code 96413.

What are the different types of infusion?

Infusion therapies can be performed for a variety of purposes. A provider will select an infusion method based on the patient’s unique physiology and medical needs. Some of the most common include:

  • IV therapy, in which medication is delivered directly into the bloodstream. Nearly anyone who has undergone surgery has received a saline solution via IV to maintain fluid levels during the procedure.
  • Epidural, in which medication is injected into the spine. This method is most commonly used to relieve pain during childbirth, but can also be used to treat severe, intractable back pain, or prepare a patient for treatments targeting the lower back or pelvis.
  • Subcutaneous, in which medicine is administered in the second layer of skin. This method is often used to deliver insulin.
  • Intramuscular, in which medication is injected into the muscles. This method is ideal for drugs that require quick absorption and slow release into the body.

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