Healthcare Insights
Top hospitals performing the most liver transplants
The liver is the largest internal organ in the human body. It has several important jobs, including processing nutrients, medications, and hormones, as well as removing bacteria and toxins from the blood. The liver helps to regulate some of the most important bodily systems, but when it’s not functioning properly, it can be detrimental to your overall health.
When patients are suffering from the complications of liver disease, many opt to have the organ removed and replaced with a healthy one. This procedure is known as a liver transplant and is one of the best treatment options for patients living with these kinds of conditions.
Using Definitive Healthcare’s Atlas All-Payor Claims product, we’ve compiled a list of the top 10 hospitals that performed the most liver transplants in 2024.
| Rank | Definitive ID | Hospital | City name | State name | # of U.S. liver transplants | Explore dataset |
|---|---|---|---|---|---|---|
| 1 | 3120 | Cleveland Clinic Main Campus | Cleveland | OH | 258 | Explore |
| 2 | 1365 | IU Health Methodist Hospital | Indianapolis | IN | 187 | Explore |
| 3 | 998 | Piedmont Atlanta Hospital (AKA Piedmont Hospital) | Atlanta | GA | 185 | Explore |
| 4 | 3158 | University of Cincinnati Medical Center (FKA University Hospital) | Cincinnati | OH | 170 | Explore |
| 5 | 2096 | University Hospital | Ann Arbor | MI | 137 | Explore |
| 6 | 2837 | The Mount Sinai Hospital (AKA Mount Sinai Medical Center) | New York | NY | 137 | Explore |
| 7 | 178 | Mayo Clinic Hospital - Arizona | Phoenix | AZ | 135 | Explore |
| 8 | 3923 | William P Clements Jr University Hospital (FKA UT Southwestern University Hospital - St Paul) | Dallas | TX | 120 | Explore |
| 9 | 588 | Stanford Hospital - 300 Pasteur Dr | Palo Alto | CA | 111 | Explore |
| 10 | 792 | Mayo Clinic Hospital - Florida | Jacksonville | FL | 79 | Explore |
Fig 1. Data is from Definitive Healthcare’s Atlas All-Payor Claims product for the calendar year 2024. Claims data is sourced from multiple medical claims clearinghouses in the United States and updated monthly. Accessed May 2025.
Which hospitals performed the most liver transplants in 2024?
In 2024, Cleveland Clinic Main Campus performed the highest percentage of liver transplants in the U.S., accounting for 258 total transplants nationwide. Located in Cleveland, Ohio, the Cleveland Clinic Main Campus is one of the largest hospitals in the country by bed count.
The hospital that performed the second highest number of liver transplants by percentage is IU Health Methodist Hospital, which performed 187 liver transplants in 2024. Located in Indianapolis, Indiana, this facility is affiliated with Indiana University as a leading academic medical center (AMC) and is one of the top hospitals in the U.S. by both net patient revenue and total outpatient claims.
Rounding out the top three is Piedmont Atlanta Hospital, accounting for 185 liver transplants in 2024. This facility located in Atlanta, Georgia, is highly regarded for its development of advanced technology to assist with organ transplants.
Mitigating organ transplant risk
An organ transplant is a surgical procedure that involves removing an organ from one person (donor) and inserting it into the body of another (recipient). A person may need an organ transplant because of a disease that caused their organ to fail.
Many organs can be transplanted, including the liver, kidney, heart, lungs, and pancreas.
While organ transplantation can extend a patient’s life, improve their quality of life, and reduce the risk of chronic illness, the procedures are not without risks.
Biopharma products like immunosuppressive drugs, monoclonal and polyclonal antibodies, and anti-infective prophylactics help prevent common complications including organ rejection and infection. When employed appropriately, these products promote long-term graft survival and organ function.
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