Start of Main Content

Healthcare Insights

Top 20 vaccines administered by physicians in 2021

The WHO defines vaccines as “simple, safe, and effective ways of protecting you against harmful diseases, before you come into contact with them.” By introducing small amounts of killed, weakened, or modified forms of pathogens (e.g., viruses and bacteria) the vaccine triggers your immune response and strengthens your body’s natural defenses.

Of course, when thinking about the most administered vaccines in 2021, the new class of mRNA vaccines to help fight the COVID-19 pandemic are at the top the list. In fact, according to Our World in Data, more than 609 million doses of the COVID-19 vaccine were administered just in the United States. However, the COVID-19 vaccines show up at the very bottom of the Top 20 physician-administered vaccines because the vast majority of COVID vaccines were delivered not by physicians, but rather by retail pharmacies, urgent care clinics, school-based vaccine programs, or hospital-administered programs.

Since August was National Immunization Awareness month, we wanted to highlight the top 20 vaccines administered by physicians in 2021, calculated using data from the Definitive Healthcare platform. We used de-identified, all-payor prescription claims data from the Definitive Healthcare ClaimsMx product to highlight the 20 most administered vaccines by physicians for calendar year 2021.

Top 20 vaccines administered by physicians

RankHCPCS/CPT codeHCPCS/CPT descriptionVirus / condition treated% totalExplore dataset
190686IIV4 VACC NO PRSV 0.5 ML IMInfluenza18.00%Explore
290670PCV13 VACCINE IMPneumococcal disease8.20%Explore
390715TDAP VACCINE 7 YRS/> IMDiphtheria, Tetanus, and Whooping Cough7.80%Explore
490633HEPA VACC PED/ADOL 2 DOSE IMHepatitis A Vaccine for Children4.50%Explore
5906519VHPV VACCINE 2/3 DOSE IMHPV (Human Papillomavirus)4.50%Explore
690680RV5 VACC 3 DOSE LIVE ORALRotavirus3.90%Explore
790662IIV NO PRSV INCREASED AG IMInfluenza and Pneumococcal virus3.80%Explore
890734MENACWYD/MENACWYCRM VACC IMMeningococcal disease3.70%Explore
990698DTAP-IPV/HIB VACCINE IMDiphtheria, tetanus, pertussis (whooping cough), polio, and Haemophilus influenzae type b3.20%Explore
1090723DTAP-HEP B-IPV VACCINE IMDiphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type b, hepatitis B2.60%Explore
1190716VAR VACCINE LIVE SUBQMeasles, mumps, rubella, and varicella (chickenpox)2.50%Explore
1290707MMR VACCINE SCMeasles, mumps, and rubella2.50%Explore
1390648HIB PRP-T VACCINE 4 DOSE IMHaemophilus b2.50%Explore
1490744HEPB VACC 3 DOSE PED/ADOL IMHepatitis B2.30%Explore
1590688IIV4 VACCINE SPLT 0.5 ML IMInfluenza2.30%Explore
1690750HZV VACC RECOMBINANT IMShingles2.10%Explore
1790700DTAP VACCINE < 7 YRS IMDiphtheria, tetanus, and acellular pertussis2.00%Explore
1891300SARSCOV2 VAC 30MCG/0.3ML IMCOVID19 (Pfizer/BioNTech)2.00%Explore
1991301SARSCOV2 VAC 100MCG/0.5ML IMCOVID19 (Moderna)1.90%Explore
2090674CCIIV4 VAC NO PRSV 0.5 ML IMInfluenza1.90%Explore

Fig. 1 Data is from the Definitive Healthcare Claims Mx product for calendar year 2021. Claims data is sourced from multiple medical claims clearinghouses in the United States and is updated monthly. Data is accurate as of August 2022.

What are the most highly administered vaccines?

Based on Definitive Healthcare ClaimsMx data, the most commonly administered vaccine was the flu vaccine, which accounted for 18% of all vaccines administered by physicians 2021. Additional top vaccines on the list protected patients against pneumococcal disease, diphtheria, tetanus, and whooping cough.

Learn more

Healthcare Insights are developed with healthcare commercial intelligence from the Definitive Healthcare platform. Want even more insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians and other healthcare providers.