Top 20 vaccines administered by physicians in 2021

The WHO defines vaccines as “simple, safe, and effective ways of protecting you against harmful diseases, before you come into contact with them.” By introducing small amounts of killed, weakened, or modified forms of pathogens (e.g., viruses and bacteria) the vaccine triggers your immune response and strengthens your body’s natural defenses.

Of course, when thinking about the most administered vaccines in 2021, the new class of mRNA vaccines to help fight the COVID-19 pandemic are at the top the list. In fact, according to Our World in Data, more than 609 million doses of the COVID-19 vaccine were administered just in the United States. However, the COVID-19 vaccines show up at the very bottom of the Top 20 physician-administered vaccines because the vast majority of COVID vaccines were delivered not by physicians, but rather by retail pharmacies, urgent care clinics, school-based vaccine programs, or hospital-administered programs.

Since August was National Immunization Awareness month, we wanted to highlight the top 20 vaccines administered by physicians in 2021, calculated using data from the Definitive Healthcare platform. We used de-identified, all-payor prescription claims data from the Definitive Healthcare ClaimsMx product to highlight the 20 most administered vaccines by physicians for calendar year 2021.

Top 20 vaccines administered by physicians

Rank HCPCS/CPT Code HCPCS/CPT Description Virus / Condition Treated % Total
1 90686 IIV4 VACC NO PRSV 0.5 ML IM Influenza 18.00%
2 90670 PCV13 VACCINE IM Pneumococcal disease 8.20%
3 90715 TDAP VACCINE 7 YRS/> IM Diphtheria, Tetanus, and Whooping Cough 7.80%
4 90633 HEPA VACC PED/ADOL 2 DOSE IM Hepatitis A Vaccine for Children 4.50%
5 90651 9VHPV VACCINE 2/3 DOSE IM HPV (Human Papillomavirus) 4.50%
6 90680 RV5 VACC 3 DOSE LIVE ORAL Rotavirus 3.90%
7 90662 IIV NO PRSV INCREASED AG IM Influenza and Pneumococcal virus 3.80%
8 90734 MENACWYD/MENACWYCRM VACC IM Meningococcal disease 3.70%
9 90698 DTAP-IPV/HIB VACCINE IM Diphtheria, tetanus, pertussis (whooping cough), polio, and Haemophilus influenzae type b 3.20%
10 90723 DTAP-HEP B-IPV VACCINE IM Diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type b, hepatitis B 2.60%
11 90716 VAR VACCINE LIVE SUBQ Measles, mumps, rubella, and varicella (chickenpox) 2.50%
12 90707 MMR VACCINE SC Measles, mumps, and rubella 2.50%
13 90648 HIB PRP-T VACCINE 4 DOSE IM Haemophilus b 2.50%
14 90744 HEPB VACC 3 DOSE PED/ADOL IM Hepatitis B 2.30%
15 90688 IIV4 VACCINE SPLT 0.5 ML IM Influenza 2.30%
16 90750 HZV VACC RECOMBINANT IM Shingles 2.10%
17 90700 DTAP VACCINE < 7 YRS IM Diphtheria, tetanus, and acellular pertussis 2.00%
18 91300 SARSCOV2 VAC 30MCG/0.3ML IM COVID19 (Pfizer/BioNTech) 2.00%
19 91301 SARSCOV2 VAC 100MCG/0.5ML IM COVID19 (Moderna) 1.90%
20 90674 CCIIV4 VAC NO PRSV 0.5 ML IM Influenza 1.90%

Fig. 1 Data is from the Definitive Healthcare Claims Mx product for calendar year 2021. Claims data is sourced from multiple medical claims clearinghouses in the United States and is updated monthly. Data is accurate as of August 2022.

What are the most highly administered vaccines?

Based on Definitive Healthcare ClaimsMx data, the most commonly administered vaccine was the flu vaccine, which accounted for 18% of all vaccines administered by physicians 2021. Additional top vaccines on the list protected patients against pneumococcal disease, diphtheria, tetanus, and whooping cough.

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