Top 25 drugs used in outpatient procedures

There is a growing emphasis on outpatient care in the United States. Outpatient care facilities play an important role in reducing healthcare costs while also satisfying patient desires for convenient, quality care.

Outpatient care is especially important for coordinating care for patients with chronic conditions since their conditions can require frequent doctor visits.

In this Healthcare Insight, we use Definitive Healthcare ClaimsMx data from PhysicianGroupView to review medications administered during outpatient visits from January to August 2022. We filtered our data by the chemotherapy and drugs not administered orally Healthcare Common Procedure Coding System (HCPCS) sub-categories, which include infused and injected medications that are billed as a procedure.

Top medication administration procedures

RankHCPCS codeHCPCS descriptionPercent of outpatient encounters
1J3301Triamcinolone acetonide, injection, 10mg12.3%
2J1100Dexamethasone sodium phosphate, injection, 1mg8.1%
3J3420Vitamin B-12 injection, 1000mcg4.2%
4J1885Ketorolac tromethamine, injection, 15mg3.8%
5J0178Alfibercept, injection, 1mg3.7%
6J0702Betamethasone acetate and betamethasone sodium phosphate, injection, 3 mg3.4%
7J0696Ceftriaxone sodium, injection, 250mg3.2%
8J1030Methylprednisolone acetate, injection, 40mg3.2%
9J9035Bevacizumab, injection, 10mg2.9%
10J3490Unclassified drugs, injection2.4%
11J1071Testosterone cypionate, injection, 1mg2.2%
12J1040Methylprednisolone acetate, injection, 80mg2.1%
13J1050Medroxyprogesterone acetate, injection, 1mg1.7%
14J1200Diphenhydramine HCL, injection, 50mg1.6%
15J2785Regadenoson, injection, 0.1mg1.6%
16J0585OnabotulinumtoxinA, injection, 1 unit1.5%
17J7030Normal saline solution, infusion, 1000cc1.4%
18J7050Normal saline solution, infusion, 250cc1.1%
19J2405Ondansetron hydrochloride, per 1mg1.1%
20J0897Denosumab, injection, 1mg1.1%
21J2469Palonosetron HCL, injection, 25mcg1.0%
22J1756Iron sucrose, injection, 1mg1.0%
23J2930Methylprednisolone sodium succinate, injection, 125mg0.9%
24J2778Ranibizumab, injection, 0.1mg0.8%
25J2357Omalizumab, injection, 5mg0.8%

Fig. 1 Data is from the Definitive Healthcare ClaimsMx and PhysicianGroupView products from January to August 2022. Claims data is sourced from multiple medical claims clearinghouses in the United States and is updated monthly. Data accessed September 2022.

What are the most common injected or infused medications?

Triamcinolone acetonide (J3301) and dexamethasone sodium phosphate (J1100) account for nearly one-quarter of chemotherapy and injection/infusion medications on the list. Both are used to treat arthritis, a common inflammatory condition.

Vitamin B injections (J3420) for deficiencies of the vitamin, ketorolac tromethamine (J1885) for pain management, and aflibercept (J0178) for age-related macular degeneration (AMD) complete the top five drugs used in outpatient procedures list.

What conditions do injected and infused medication treat?

Additional conditions treated by medications on the list include:

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Healthcare Insights are developed with healthcare commercial intelligence from the Definitive Healthcare platform. Want even more insights? Start a free trial now and get access to the latest healthcare commercial intelligence on hospitals, physicians, and other healthcare providers.

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